C. neoformans is the most common cause of fungal meningitis (reviewed in [47], and the invasion of the central nervous system by C. neoformans is strictly dependent on the secretion of proteins like phospholipase B1 (Plb1) [11], the metalloprotease Mpr1 [48], building blocks of the capsule, and enzymes involved in the assembly, maintenance and integrity of the cell wall as well as other proteins [12] [49]. Here, IGF2R is linked to fungal meningitis.