CXCL2 and Alzheimer disease: Similarly, the present study showed that, in the early stage of an antigen-induced immune response, AD particles can increase the number of neutrophils, the concentration of MIP-2/CXCL2 (a murine homologue of IL-8), and the concentration of LTB4 in the setting of co-exposure to AD particles and antigen in BALF.