The enhanced secretion of lysophosphatidic acid (LPA) and TGF-β, supposedly by tumor cells, initially promotes matrix remodeling by stromal fibroblast, a process that requires Rho/ROCK/ Myosin Light Chain 9 (MYL9)/MLC-mediated changes in their contractile actin cytoskeleton. The gene discussed is MYL9; the disease is neoplasm.