However, that study only evaluated the acute effects of tea compared with hot water, with a mixed meal (not specifically a fat load) in pharmacologically treated patients (with a number of putative confounding treatments: the use of aspirin, statins, or specific antihypertensive medications including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium channel entry blockers, and diuretics) at very high cardiovascular risk (with coronary artery disease) aged between 45 and 70 years. This evidence concerns the gene ACE and coronary artery disorder.