Similarly, the HDACi, FR901228, facilitated a time- and concentration-dependent increase in HLA-A/B surface/intracellular protein and RNA expression in leukemia and increased HLA-A/B surface expression in hematological and colon malignancies by potentiating the activity of glycogen synthase kinase (GSK-3β) [56]. This evidence concerns the gene HLA-A and leukemia.