In addition, HLA-B RNA expression is elevated in ovarian cancer patients treated with paclitaxel-carboplatin and exposure of paclitaxel or gemcitabine to murine or human ovarian cancer lines results in a concentration-dependent increase in intracellular and surface MHC class I protein expression in vitro and in vivo [43,52]. This evidence concerns the gene HLA-B and ovarian carcinoma.