Here, the activation of the Wnt/β catenin pathway through a tumor-intrinsic manner resulted in the inhibition of T cell infiltration into the tumor and resistance to monotherapies using antibodies against PD-L1 and CTLA-4 [100], suggesting that targeted Wnt antagonists, which are entering the clinic, may promote TIL accumulation and response to immune checkpoint blockade. Here, CTLA4 is linked to neoplasm.