CD4 and neoplasm: Interestingly, Ding et al. demonstrated that in mice with lymphoma, pre-conditioning of the host via cyclophosphamide prior to adoptive transfer of antigen-specific CD4+ T cells resulted in a robust anti-tumor immune response, but drove the expansion of immunosuppressive monocytic myeloid cells characterized by CD11b+, Ly6Chi and CCR2hi [76].