Other studies show that c-Cbl selectively monoubiquitinates KSHV entry receptors integrin β1 and β3 molecules to facilitate KSHV macropinocytosis in HMVEC-d cells leading towards a successful infection whereas it polyubiquitinates integrin β5 to direct clathrin mediated KSHV endocytosis and for directing KSHV towards lysosomal degradative pathways [30]. The gene discussed is CBL; the disease is infection.