Further studies revealed that disruption of LRs increases the induction of p-Src by KSHV without affecting FAK or ERK1/2 activation but greatly reduces the activation of PI3-K, Rho-GTPase, and NF-κB, and subsequently abolishing RhoA mediated acetylation and microtubule aggregation which are important events during entry stages of infection, trafficking of KSHV in cytoplasm and nuclear delivery of viral genome [83]. This evidence concerns the gene PTK2 and infection.