One is that we could not directly clarify that hANP prevents an increase in postoperative serum Cr, although it did reduce the incidence of AKI, as determined by serum Cr levels based on the definition of AKI, probably because of the small sample size, although hANP could inhibit the secretion of urinary NGAL and L-FABP. This evidence concerns the gene LCN2 and acute kidney injury.