CD3+CD8− cells (presumably composed of CD4+ and γδ T cells) constituted 49 and 47% of the T-cell infiltrate in primary tumours and metastases, while this proportion was observed lower (36%) but without statistical significance (p = 0.73) in local relapses (Fig. 2e and Supplementary Table 1). This evidence concerns the gene CD8A and neoplasm.