An expanding signs of EC molecular diversity [see f.e. data on POLE gene mutations analysis (Cancer Genome Atlas Research Network et al. 2013; Murali et al. 2014)] is also ‘an item’ to be considered during analysis of obesity connection with risk factors, as well as with clinical and morphologic features of EC. The gene discussed is POLE; the disease is obesity due to melanocortin 4 receptor deficiency.