In comparison to degree-based hubs, the top 20 contextual hubs were statistically enriched in pathways related to the immune response to viral infection, such as the interferon signaling pathway; the Retinoic acid inducible gene-I (RIG-I) pathway; the Toll-like receptor (TLR) pathway; and the Janus kinase (JAK) - Signal Transducer and Activator of Transcription (STAT) pathway (Supplementary Table 2). Here, RIGI is linked to viral infectious disease.