Jin and co-workers reported TrkC and its tyrosine kinase activity mediated tumorigenesis (protumor) through suppression of the tumor suppressor TGF-β signaling21, which is different from our study which showed conjugate-activated TrkC administered in dark inhibited TGF-β production and delayed tumorigenesis (antitumor). Here, TGFB1 is linked to neoplasm.