Secondly, while the histopathological parameters in mice treated with IL-17A or IL-17F neutralizing antibodies were comparable to those of vehicle or isotype controls, anti-TNFα-antibody-treated animals showed a distinct reduction of free alveolar space, concurrent with high inflammatory cell infiltration in the lungs, oedema and necrotic pneumonia in response to early phase M. tuberculosis infection at day 28 (Fig. 1D). This evidence concerns the gene TNF and pneumonia.