For example, the lncRNA NRF regulates programmed necrosis and myocardial injury during ischaemia and reperfusion by targeting miR-873; MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression; and Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression32, 33. The gene discussed is FOXO1; the disease is Insulin resistance.