When compared to unstimulated cells, cardiomyocytes exposed to human sepsis serum (for 24 h) showed a significant decrease of SERCA2 mRNA (P < 0.0001) and SERCA2 protein expression measured by western blot (P < 0.0001) and immunofluorescence (P = 0.0009) (Fig. 8). This evidence concerns the gene ATP2A2 and Sepsis.