The addition of Pep2.5 (20 μg/ml), however, significantly attenuated the decrease of SERCA2 mRNA (P < 0.0001) and SERCA2 protein expression measured by western blot (P < 0.0001) and immunofluorescence (P = 0.0009) in cardiomyocytes exposed to human serum from septic shock patients (Fig. 8). This evidence concerns the gene ATP2A2 and septic shock.