IGFBP3 and cancer: Finally, IPA network analysis showed that, for miRNA enriched in ERMS-derived exosomes, there were 8 significantly represented networks, 3 of which included more than one identified focus miRNA, with nodes centering on proteins implicated in cancer cell cycle biology such as Cyclin D1 (CCND1) (Fig. 3a); IGFBP3, AKT1, SP1, HMGA1, NFYB, and YBX1 (Fig. 3b); and CDKN2A (Fig. 3c).