Significantly represented networks featured proteins previously implicated in ARMS biology (GSK3b, MDM2, CDKN1A, CDKN2A, IGF1R)43, 44, 45, 46, 47, proteins involved in immune evasion and tumor metastasis (CXCL8, CSF1, IFNAR1, CCR2, CASR)48, 49, 50, 51, 52, stemness (SOX2, POU5F1)53, 54, tumor cell proliferation and invasion (YBX1)41, or have been associated with other tumor types with a possible role in tumor biology (PRKACA, MYO1C, BRINP3)55, 56, 57. This evidence concerns the gene IGF1R and neoplasm.