Furthermore, similar results were obtained when using FcγRIIlow/− B cells that were induced by HCC-SN-treated DCs: FcγRIIlow/− B cells suppressed the expression of proinflammatory TNF-α and IFN-γ and cytotoxic granzyme B and perforin in autologous tumour-derived CD8+ T cells via an IL-10-dependent manner (Supplementary Fig. 5c). Here, TNF is linked to hepatocellular carcinoma.