More interestingly, inhibiting the activation of IκBα, but not Jnk, Erk or p38, in HCC-SN-exposed monocytes could significantly attenuate the sequential DC semimaturation, and B-cell activation and IL-10 production (Fig. 3h,i and Supplementary Fig. 3b). This evidence concerns the gene NFKBIA and hepatocellular carcinoma.