Supporting the protumorigenic roles of FcγRIIlow/− B cells, high infiltration of FcγRIIlow/− B cells in HCC tumours positively correlated with dysfunction of tumour-derived CD8+ T cells with impaired capacities for production of proinflammatory TNF-α and IFN-γ and cytotoxic granzyme B and perforin (Fig. 5b). This evidence concerns the gene PRF1 and hepatocellular carcinoma.