In conclusion, the positive correlation of CUGBP1 expression in clinical samples with liver fibrosis severity supports the hypothesis, the interaction of CUGBP1-IFN-γ mRNA as a key molecular event that connects the opposite TGF-β and IFN-γ signalling pathways in the activation or homeostasis of HSCs. The gene discussed is CELF1; the disease is Hepatic fibrosis.