For example, tumor-derived VEGF-C and associated lymph node lymphangiogenesis suppressed anti-tumor immunity in a murine melanoma model; this type of immunomodulatory effect, involving an immunosuppressive function of lymphatic endothelial cells (LECs),3 may be relevant for the design of future immunotherapeutic strategies for cancer (18, 19). The gene discussed is VEGFC; the disease is cancer.