Given our results in cellular models above, we examined if ADA3 overexpression in ER+ breast cancer patients correlates with c-MYC expression using a large unselected cohort of primary invasive breast cancer specimens that includes various subtypes of breast cancer and in which c-MYC overexpression is known to be significantly associated with poor prognostic factors, including tumor grade and basal-like breast cancer phenotype [30]. This evidence concerns the gene MYC and invasive breast carcinoma.