Analyses of a well characterized cohort of breast cancer tissue samples for nuclear ADA3 and c-MYC expression helped categorize breast cancers into four groups; ADA3 Low/c-MYCLow, ADA3High/c-MYCLow, ADA3Low/c-MYCHigh and ADA3High/c-MYCHigh group of patients. This evidence concerns the gene TADA3 and breast carcinoma.