MKI67 and neoplasm: Analysis of these groups of patterns of nuclear ADA3 and nuclear c-MYC co-expression within the ER+ tumors only (432 cases) with various clinico-pathological parameters and molecular markers showed a significant association of ADA3/c-MYC co-expression with tumor grade, nuclear pleomorphism, NPI, LVI, histologic tumor type, and the expressions Ki67 and p27 (Table 4).