Based on AChE assay, the serum levels of exosomes were significantly higher in SLE patients (n =13) than in HCs (n = 8) (median with interquartile range (IQR), μL: 43.10 × 107 (9.61 × 107–58.44 × 107) vs. 10.07 × 107 (5.36 × 107–13.01 × 107), respectively; p = 0.023) (Fig. 1b). The gene discussed is ACHE; the disease is systemic lupus erythematosus.