For instance, murine high fat diet model of obesity exposed to anti-obesity drug (orlistat) or restricted caloric intake had smaller adipocyte size, low CAV1 and suppressed adipokines (leptin and resistin) – in vivo growth of murine (B16F10) and human (A375) melanoma cell lines was also reduced in the obese mice [97]. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.