The role of miR-125b in cancer progression has also been studied extensively – in melanoma miR-125b over-expression reduces cell proliferation and migration, mediated partly by the direct suppression of c-JUN mRNA translation [16]; however, much of the literature has examined miR-125b-5p (the dominant mature form; Fig. 3a, seventh column), rather than the -3p forms. This evidence concerns the gene JUN and melanoma.