In this study, SCP, an active component of Schisandra, improved liver function and alleviated fatty degeneration in the liver in NAFLD mice, an effect which appears to be mediated via down-regulation of LXRα/SREBP-1c/FAS/ACC and SREBP-2/HMGCR signaling pathways in the liver. Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.