This relationship arise from this fact that adipocytes, specially white adipose tissue cells, produce VEGF which may act as an angiogenic and vascular survival factor for the omental vasculature and has paracrine or systemic endocrine actions, these might hypothetically impact on adipose expansion or the vascular comorbidities of obesity related disease [46]. This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.