In seven of these children (patients 1–7), the diagnosis of CD was confirmed by paediatric gastroenterologists: (a) through multiple duodenal biopsies (subjects 1–5); (b) on the basis of very high anti-tTG antibody levels and HLA positivity (patient 6); (c) on the presence of Duhring-Brocq dermatitis herpetiformis, a chronic bullous disease specifically correlated with sensitivity to gluten enteropathy and CD (patient 7) [34]. The gene discussed is TGM2; the disease is dermatitis herpetiformis.