UICC stage (RR = 1.198, 95% CI: 1.095-1.311, P < 0.001),PSA (RR = 1.091,95% CI: 1.040-1.143,P < 0.001) and Gleason score (RR = 1.635, 95% CI: 1.514-1.765, P < 0.001) are independent risk factors for overall survival in prostate cancer patients. Here, KLK3 is linked to Familial prostate cancer.