Moreover, MPC1 and MPC2 expressions are also independent prognostic factors for overall survival in PCA (For MPC1: RR = 0.654, 95% CI: 0.621-0.690, P < 0.001; For MPC2: RR = 0.696, 95% CI: 0.660-0.734, P < 0.001), while other variables including age, PSA, lymph node metastasis and distant metastasis did not contribute to overall survival independently (P > 0.05). Here, KLK3 is linked to metastatic malignant neoplasm in the lymph nodes.