EGFR and acute myeloid leukemia: Furthermore, Boehrer et al. (2008) showed that erlotinib was able to inhibit growth of acute myeloid leukemia cell xenografts [33] and explained the non-target effect of erlotinib, i.e., erlotinib-induced apoptosis and phenotypic differentiation of acute myeloid leukemia cells were not through erlotinib-inhibited EGFR tyrosine kinase receptor pathway, but could be due to inhibition of MAPK and Akt gene pathways [33].