Usually, EGFR-TKIs are used to treat patients with EGFR mutated or amplified NSCLC, and in the current study, we explored icotinib antitumor activity after it was combined with (or sequential to) docetaxel in growth of wild-type EGFR A549 cells-generated nude mouse xenografts. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.