Thus, the National Comprehensive Cancer Network (NCCN) guidelines recommend that patients with EGFR-mutated NSCLC should receive TKI treatment, while patients with wild-type EGFR NSCLC can be treated with chemotherapy [22], although chemotherapy alone cannot improve or control disease progression in the vast majority of NSCLC patients [23]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.