In the present study, our data suggest that FZD7 promotes glioma cell proliferation via upregulation of TAZ, and FZD7 may enhance the expression of TAZ through β-catenin/TCF-mediated transcription in glioma cells, which is consistent with the oncogenic role of TAZ in glioma previously reported [59, 62]. This evidence concerns the gene HNF4A and central nervous system cancer.