Furthermore, FZD7 directly regulated the expression of transcriptional coactivator with PDZ-binding motif (TAZ) (also known as WW domain containing transcription regulator 1, WWTR1) [25, 26] in glioma cells, suggesting that FZD7 may promote glioma cell proliferation via upregulation of TAZ. This evidence concerns the gene WWTR1 and central nervous system cancer.