In contrast, the SENP1-Tg and PTEN+/−bigenic mouse (PTEN+/−,Tg) has local invasive carcinoma in the anterior and dorsolateral lobes of the prostate gland of 10-month mice (red arrows, Figure 6A and 6B) with corresponding thickening of the surrounding stroma (black arrow, Figure 6A and 6B). The gene discussed is SENP1; the disease is invasive carcinoma.