TLE1 and lung adenocarcinoma: It is a putative lung-specific oncogene that positively regulates Bcl2 expression and ErbB1/ErbB2 signaling to promote cancer progression [30].Interestingly, Yao et al. demonstrated that TLE1 promoted epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells through transcriptional silencing of E-cadherin [31].