Three years later, Zhang et al. found that MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting TLE1 through NFkB pathways [44], which confirms the functions of TLE1 in hepatocellular carcinoma and provides new insight into the potential molecular mechanisms of hepatic carcinogenesis. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.