Points for the following factors were added to the total points, which corresponded to the linear predictors and risk predictors of ALN metastasis (Figure 3): size (T1, 0; T2, 7; T3, 23), location (LIQ, 0; UIQ, 17; UOQ, 31; LOQ, 41; central, 49; others, 27), invasion (no, 0; yes, 26), lymph node (no, 0; yes, 42), pathology (DCIS-Mi, 0; ILC, 98; IDC, 100; others, 72), subtype (TN, 0; HER2+, 5; LM, 11). This evidence concerns the gene ERBB2 and ductal breast carcinoma in situ.