The latest classification of IDH-mutant glioma groups into two subtypes: one with 1p/19q co-deletion also harboring mutations in CIC, FUBP1, and NOTCH1, and the other without 1p/19q co-deletion but with extreme high frequencies of mutations in TP53 and ATRX [2,29]. Here, NOTCH1 is linked to central nervous system cancer.