Furthermore, differential IGFBP2 expression between IDH-wildtype and IDH-mutant gliomas was seen with strong statistical significance across all three histological types, and increased IGFBP2 expression correlated with higher grade (Figure 6B and 6C), a finding that supports the general role of IGFBP2 in glioma progression. Here, IDH1 is linked to central nervous system cancer.