Furthermore, within the IDH-mutant group, IGFBP2 was the only gene that was still prognostic at the mRNA levels; the median overall survival of IDH-mutant gliomas with high IGFBP2 expression was ~25% worse than that of IDH-wildtype (Figure 5A and 5B; Table S2). Here, IGFBP2 is linked to central nervous system cancer.