Furthermore, no statistical differences in IGFBP2 expression were observed between subtypes with and without CIC, FUBP1, and/or NOTCH1 mutations, nor between those with and without TP53 and/or ATRX mutations, which further disputes the possibility of IGFBP2 association with specific glioma subtypes. The gene discussed is NOTCH1; the disease is central nervous system cancer.