We demonstrate here the strong statistical correlations of IDH-mutant gliomas with increased expression of mostly intact tumor-suppressor genes (NF1, PIK3R1, and PTEN), and decreased expression of oncogenic genes (ERBB2, FGFR3, PDGFRB, AKT2, and ARAF) and progression genes (IGFBP2, FOXM1, and WWTR1). Here, PTEN is linked to central nervous system cancer.