We demonstrate here the strong statistical correlations of IDH-mutant gliomas with increased expression of mostly intact tumor-suppressor genes (NF1, PIK3R1, and PTEN), and decreased expression of oncogenic genes (ERBB2, FGFR3, PDGFRB, AKT2, and ARAF) and progression genes (IGFBP2, FOXM1, and WWTR1). The gene discussed is PIK3R1; the disease is central nervous system cancer.