GIP and hypertensive disorder: In the GOG218 trial patients treated with the dose of 15 mg/kg of BV experienced a worse toxicity profile than patients treated with 7.5 mg/kg of BV in ICON7 trial: hypertension ≥ 2 (p = 0.003), GIP ≥ 2 (p = 0.028), proteinuria ≥ 3 (p = 0.017).