Finally, we extended our gene expression signature analysis into other well-recognized Warburg metabolism regulatory genes PKM2, LDHA, ENO1, TPI1 and GAPDH, and found that they were all adaptively downregulated in expression within the EGFR-mutant NSCLC cells under EGFR-TKI drug escape (Figure 3C). This evidence concerns the gene PKM and non-small cell lung carcinoma.