Histologically, the breast carcinoma was classified as LBC, with some areas of in situ component, stage pT2 pN2a Mo (5/15 axillary lymph nodes with metastatic disease), and with immunohistochemistry characteristics of Luminal A subtype (ER60%+, PR50%+, HER-2 negative and Ki67 5% positivity). The gene discussed is MKI67; the disease is metastatic neoplasm.