Using the ID8 murine model of ovarian cancer we showed significantly greater anti-tumor efficacy with dabigatran etexilate and cisplatin co-treatment that was accompanied by a decrease in immunosuppressive myeloid cell populations and pro-tumorigenic cytokines as well as a concomitant increase in CD8+ effector T-cell activity in the tumor ascites. The gene discussed is CD8A; the disease is ovarian carcinoma.