Liu Y, et al. analyzed the effect of NHEJ pathway gene (eg: XRCC5, XRCC4 gene) on glioma in 771 case and 752 controls, found that rs3770502 and rs9288516 in XRCC5 gene and rs1056503 in XRCC4 gene increased the risk of glioma [6, 7]. Here, XRCC4 is linked to central nervous system cancer.