SRSF10 and cancer: Thus, SRSF10 controls a complex functional network because it suppresses splicing during heat shock and M phase (Shin et al., 2004; Shin and Manley, 2002), controls alternative splicing decisions that elicit myoblast differentiation and glucose production, alters the oncogenic properties of cancer cells (Wei et al., 2015; Zhou et al., 2014a), and modulates the production of splice variants implicated in apoptosis, cell-cycle control, and DNA repair as part of the cellular response to DNA damage.