Th17-cell-derived IL-17A and IL-17F promote the expression of chemokines such as CXCL1 and CXCL5 in the kidney and thereby drive recruitment of neutrophils and other leukocyte subtypes, which mediate renal tissue destruction in cGN (Disteldorf et al., 2015, Turner et al., 2010). The gene discussed is IL17F; the disease is childhood gender nonconformity.