Fig 9A indicates results of experiments using several human breast cancer cells lines prior to xenotransplantation. As shown in Fig 9A, PLD2, GM-CSF, IL-8 and Rac2 (which is important for cell chemotaxis and metastasis [52]) were significantly increased in PLD2-overexpressing MCF-7 cells and significantly decreased in PLD2-silenced MDA-MB-231 cells. This evidence concerns the gene RAC2 and breast cancer.