PPP2CA and familial dilated cardiomyopathy: Thus, we hypothesized that the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in HG and in an experimental model of DCM might depend upon inactivation of GSK-3β and subsequent activation of PP2Ac, as well as on suppression of the sustained activation of the NF-κB signaling pathway.