Thus, the anti-apoptotic and cardioprotective effects of ATOR in HG-treated cardiomyocytes and in an experimental model of DCM may depend upon GSK-3β inactivation and subsequent PP2Ac activation, as well as on suppression of the constitutive activation of the NF-κB signaling pathway. Here, PPP2CA is linked to familial dilated cardiomyopathy.