For example, p53 was found to be highly elevated in brains affected by several neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), HIV-associated neurocognitive disorders (HAND), etc. [59]. The gene discussed is TP53; the disease is early-onset autosomal dominant Alzheimer disease.