MBD3 and neoplasm: In addition, Mbd3/NuRD coordinates cytosine methylation by recruiting DNA methyltransferases to the promoters of tumor suppressor genes in colon cancer cell and leukemia cell lines (Cai et al., 2014; Choi et al., 2013; Morey et al., 2008), and depletion of Mbd3 results in reduced DNA methylation levels at some locations in ES cells (Latos et al., 2012).