We have previously shown thatdietary nitrate prevents an increase in systolic blood pressure and serum glucose,improves glucose tolerance, and restores dyslipidemia in STZ-NA-induced diabeticrats.15 Jiang etal.33 have reported thatdietary nitrite (50 mg/L for 4 weeks) in db/db diabetic mice improves insulinsignaling through GLUT4 translocation to the membrane.33 Ohtake et al. have also shown that dietary nitrite(150 mg/L for 10 weeks) improves insulin resistance in type 2 diabeticmice.14 The gene discussed is SLC2A4; the disease is Insulin resistance.