DUSP1 and Alzheimer disease: Interestingly, DUSP1 protein levels correlate with that of PSD95 (Fig. 6D), a postsynaptic marker associated with glutamatergic neurotransmission that is downregulated in the AD group (–59.92 ± 9.52% in 24 AD versus 17 CTR, unpaired t-test P = 0.008 and36) and in a mouse model of tauopathy37.