Elucidating the signaling pathways downstream of GR phosphorylation that are involved in activity-dependent formation/maintenance of synaptic connections and tau phosphorylation could provide insightful information about neuronal (mal)adaptation to chronic glucocorticoid exposure and diseases featuring hypercortisolemia as a risk factor (e.g. AD, cognitive impairment). The gene discussed is MAPT; the disease is Alzheimer disease.