Experimentally, we confirmed genotype-dependent differential looping (altered 3D organization) in the 17q21 locus that resulted in the recruitment of active cell-specific cis-regulatory elements (for example, of the 5′ IKZF3 proximal region which overlaps the asthma-risk SNP rs4795397) to the ORMDL3 promoter in asthma-risk alleles. The gene discussed is ORMDL3; the disease is asthma.