ORMDL3 and asthma: Our results suggest that the 3D organization of the 17q21 locus is modified in memory CD4+ T cells from subjects with the 17q21 asthma-risk alleles to favour selective recruitment of the IKZF3 cis-regulatory elements to the ORMDL3 promoter region (Fig. 5d), which correlated with its increased transcriptional activity.