Previous studies have examined the function of the conserved ORM family proteins in yeast48, 49 (which includes ORMDL3 in humans), as well as ORMDL3 itself in various mammalian cell lines and in primary cell types relevant to asthma pathogenesis such as epithelial cells, eosinophils, mast cells and whole PBMCs23, 43, 44, 45, 50, 51, 52, 53, 54. The gene discussed is ORMDL3; the disease is asthma.