Three asthma-risk SNPs (rs4065275, rs8076131 and rs12603332) overlapped DHS in the first intron of ORMDL3 (Fig. 3a, top panel); this ∼3.0 kb intronic region was also highly enriched for the H3K27ac mark, suggestive of active enhancer activity, in CD4+ T cells but not monocytes (Fig. 3a, bottom panel). This evidence concerns the gene ORMDL3 and asthma.