Altogether, our results provide strong evidence that ORMDL3 negatively regulates IL-2 production in CD4+ T cells, and that overexpression of ORMDL3 in subjects carrying the asthma-risk alleles is likely to reduce IL-2 production in vivo, which in turn may have important functional effects that contribute to the development of asthma46. The gene discussed is IL2; the disease is asthma.