Such divergent effects of the asthma-risk variants among cell types indicate that the upstream pathway positively regulating the ORMDL3 locus is sensitive to the effects of genetic variants only in certain cell types; therefore, the functional consequences of the underlying genetic risk are likely to be best observed in the cell types most sensitive to the effects of asthma-risk variants, in this case T cell subsets. This evidence concerns the gene ORMDL3 and asthma.