To do so, we first explored ex cellulo the relative specific activity of CAT (SpCAT) in various HBC cells, numerous colorectal cancer cells, diverse cellular models of neurodegenerative disorders (Hek 293T cells transfected with Htt-N171-82Q (Htt) or Alpha-synuclein-A53T (α-Syn; see Supplementary Fig. 11), and M17 human neuroblastoma cells treated with rotenone) and a rodent model of Dextran Sulfate Sodium(DSS)-induced colitis (Fig. 6a–d). Here, SNCA is linked to colitis.