To determine, whether in MS oligodendrocyte damage followed a ‘centripetal' pattern, we used the same approach as in EAE (cf. Fig. 1) and performed triple immuno-labelling to reveal oligodendrocytes (stained for NogoA), myelin (MBP) and microglia/macrophages (Iba1) on sections counterstained with the nuclear dye DAPI (Fig. 4a; Supplementary Fig. 6). Here, MBP is linked to myeloid sarcoma.