GPLD1 and retinal degeneration: We found that (i) photoreceptors contain a light-stimulated PLD activity, (ii) Loss of dPLD activity results in enhanced numbers of Rab7-positive RLVs in the cell body during illumination, (iii) overexpression of catalytically active dPLD was able to clear light-induced Rab7-positive RLVs in wild-type cells and (iv) dPLD overexpression was able to reduce the enhanced RLV number and partially suppress retinal degeneration in norpAP24, a mutant that shows enhanced Rab7 positive RLVs during illumination.