Warner et al reported a case of aggressive metastatic ACC; NGS analysis reported deletions in tumor suppressor genes CDKN2A (cyclin dependent kinase inhibitor 2A) and CKDN2B and non-sense mutation in ARID2.6 CDKN2A encodes P16INK4A and P14ARF. Here, ARID2 is linked to adrenal cortex carcinoma.